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Vidalista Tadalafil Tadalafil Cialis Cialis

Vidalista Tadalafil Tadalafil Cialis Cialis

Regular price $70.00 USD
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Tadalafil is a selective reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5). When sexual stimulation leads to the local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the level of cGMP in the corpus cavernosum of the penis, which leads to relaxation of smooth muscles, blood flow into the penile tissue, and erection; if there is no sexual stimulation, the drug may not be able to exert its effect.

Aliases: Cialis, Cialis, Cialis

Pharmacokinetics: Rapidly absorbed after oral administration, the median time after administration is 2 hours to reach the mean maximum observed plasma concentration (cmax). The absolute bioavailability of this product after oral administration has not yet been determined. The absorption rate and extent of tadalafil are not affected by food, so this product can be taken with or without food. The time of administration (morning or evening) has no clinically significant effect on the absorption rate and extent, and the average distribution volume is about 63 liters, indicating that tadalafil is distributed into tissues. At therapeutic concentrations, 94% of tadalafil in plasma is bound to proteins. Protein binding is not affected by renal impairment. In healthy subjects, the average clearance of oral tadalafil is 2.5L/hr, and the average half-life is 17.5 hours. Tadalafil is mainly excreted in the form of inactive metabolites, mainly from the feces (about 61% of the dose), and a small amount is excreted from the urine (about 36% of the dose).
Applicable symptoms include erectile dysfunction and pulmonary hypertension.

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