Afinitor (Everolimus) 5mg – Targeted Therapy for Breast Cancer

Brand Name: Afinitor®
Generic Name: Everolimus (依维莫司)
Strength: 10 mg tablets
Drug Class: mTOR inhibitor – Targeted anticancer therapy
Indication: HR-positive / HER2-negative advanced or metastatic breast cancer (in combination with endocrine therapy)

Product Overview

Afinitor (Everolimus) is a widely used targeted anticancer medication designed to inhibit the mTOR signaling pathway, which plays a key role in cancer cell growth, proliferation, and angiogenesis.

In patients with HR-positive, HER2-negative advanced breast cancer, Afinitor is commonly prescribed in combination with endocrine therapy (such as exemestane) to help restore hormonal sensitivity and delay disease progression after resistance to aromatase inhibitors.

Key Benefits

• Targeted inhibition of the mTOR pathway

• Helps overcome endocrine therapy resistance

• Improves progression-free survival (PFS) in combination therapy

• Convenient once-daily oral dosing

• Recommended in international oncology treatment guidelines

Indications

Afinitor (Everolimus) is indicated for:

• HR-positive / HER2-negative advanced or metastatic breast cancer

• Patients who have progressed after aromatase inhibitor therapy

• Patients requiring combination treatment with exemestane

• Individuals assessed by physicians as suitable for mTOR-targeted therapy

Dosage and Administration

• Recommended dose: 10 mg once daily

• Take at the same time each day

• May be taken with or without food (keep administration consistent)

• Swallow tablets whole; do not crush or chew

• Dose adjustments should only be made under medical supervision

Possible Side Effects

Common side effects:

• Mouth ulcers / stomatitis

• Fatigue

• Rash

• Diarrhea

• Decreased appetite

Less common but serious:

• Increased risk of infections

• Non-infectious pneumonitis

• Elevated blood sugar or cholesterol

Patients should consult their healthcare provider if severe symptoms occur.

Storage

• Store at room temperature

• Keep away from moisture and direct sunlight

• Keep out of reach of children

Frequently Asked Questions

Is Afinitor a chemotherapy drug?
No. Everolimus is a targeted therapy (mTOR inhibitor) rather than traditional chemotherapy.

Does Afinitor need to be combined with other medicines?
For breast cancer treatment, Afinitor is typically used in combination with endocrine therapy, such as exemestane.

How long should Afinitor be taken?
Treatment is generally continued until disease progression or unacceptable toxicity, as determined by the treating physician.

Important Notice

Afinitor (Everolimus) is a prescription anticancer medication. Use only under the supervision of a qualified healthcare professional and follow medical guidance for monitoring blood tests and treatment safety.