Introduction to Mesterolone

Introduction to Mesterolone Proviro is the brand name of Schering-Plough's (now Bayer) oral androgen mesterolone (1-methyldihydrotestosterone). Similar to dihydrotestosterone, mesterolone is a strong androgen, but has only weak anabolic activity. This is because, like dihydrotestosterone, mesterolone is rapidly reduced to an inactive diol metabolite in muscle tissue where the concentration of 3-hydroxysteroid dehydrogenase is high. Some people believe that the weak anabolic properties of mesterolone indicate a tendency to block androgen receptors in muscle tissue, thereby affecting the effects of other more potent steroids. This view should not be accepted. In fact, due to its extremely high affinity for plasma binding proteins such as SHBG, mesterolone can actually play a role in maintaining the activity of other steroids by replacing a higher percentage with a free, unbound state. 
Among athletes, mesterolone is used primarily to increase androgen levels when dieting or preparing for competition, and as an anti-estrogen due to its intrinsic ability to antagonize aromatase.

History of Proviron

According to company literature, Schering developed Proviron in 1934, which makes it a very old drug, as far as anabolic/androgenic steroids go. Schering also notes that it was the first drug to be used in clinical practice for the treatment of "hormone-related disorders and complaints in men." "Thus, Proviron was developed at roughly the same time as methyltestosterone (1935) and testosterone propionate (1937), all of which are very old drugs and are generally considered obsolete by today's standards. Despite its age, Proviron has a long history of clinical effectiveness and safety and remains in widespread clinical use today. It is commonly prescribed to men for the treatment of decreased physical and mental abilities caused by age and suboptimal androgen levels, low libido caused by inadequate androgen levels, and low libido caused by inadequate androgen levels. Proviron is widely manufactured by Bayer (formerly Schering), which currently markets the drug in more than 30 countries around the world.
The most common brand name used for sales is Proviron, although Schering/Bayer has sold the agent under other names in certain markets, including Mestronanum and Provironum. Despite its long record of safety and effectiveness, mesterolone has never been approved for sale in the United States. However, it is still available in many Western countries. Today, Bayer is still
The main (almost exclusive) global supplier of mesterolone, although other brands of the drug can be found in rare cases

Effects of Proviron

During the muscle-building period, mesterolone cannot be used as the main steroid, and it may not have a place in the off-season cycle of many male users. Of course, there are exceptions. Adding mesterolone to the muscle-building cycle may help users break through the growth plateau. Sometimes a plateau (slowing weight gain) occurs about halfway through the cycle. Mesterolone can increase the amount of free testosterone in the body, so it will help to break through the plateau. For bodybuilders, the off-season is the time to use a lot of testosterone, and some people even use high doses of testosterone during the fat-cutting period. However, for users who choose to cycle low-dose testosterone in the off-season, mesterolone can provide a certain degree of male hormone help.
There is no doubt that mesterolone is more suitable for fat loss. This steroid will increase muscle hardness, and more importantly, it can increase the efficiency of other mixed steroids in increasing muscle hardness. We have previously mentioned that mesterolone has a strong binding ability with androgen receptors, which can increase the efficiency of fat metabolism. At the same time, we must pay attention to the anti-estrone function of mesterolone, which can ensure that there are no side effects such as water retention or bitch milk in the cycle. It can also increase the amount of free testosterone in the body, which is very useful in the situation of not having so much testosterone in the body during fat loss. Finally, due to its androgenic properties, mesterolone can greatly enhance the effect of other steroids during fat loss, thereby increasing muscle hardness and definition. But it should be noted that mesterolone can only work when sebum is very low.

Side effects of Proviron

Mesterolone Side Effects (Estrogen):
Mesterolone is not aromatized by the body and is not measurably estrogenic. Antiestrogens are not necessary when using this steroid, as the drug is unlikely to induce gynecomastia, water retention, or other estrogen-related side effects. In fact, Mesterolone can act as an anti-aromatase agent, blocking or slowing the conversion of steroids to estrogens. The effects are somewhat comparable to those of anastrozole, but not as strong as anastrozole. The anti-estrogenic properties of Mesterolone are not unique, and many other steroids have demonstrated similar activity. For example, dihydrotestosterone and drostanolone have been successfully used as treatments for gynecomastia and breast cancer due to their strong androgenic and potential anti-estrogenic effects. It has also been suggested that another steroid, nandrolone (Deca), may even reduce aromatase activity in peripheral tissues, where it is more resistant to estrogen conversion (the most active site of aromatization for nandrolone appears to be the liver). The anti-estrogenic effects of all of these compounds may be caused by their ability to compete with other substrates for binding to the aromatase enzyme.
Side effects of Mesterolone (androgen):
Mesterolone is classified as an androgenic steroid. Androgenic side effects are common with this substance, especially at higher doses. This may include oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also worsen male pattern hair loss. Women are also warned of the potential masculinizing effects of anabolic/androgenic steroids. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, 5-alphai reductase does not metabolize Mesterolone, so its relative androgenicity is not affected by finasteride or dutasteride.
Mesterolone Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to decrease HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in favor of a greater risk of atherosclerosis. The relative effects of anabolic/androgenic steroids on serum lipids depend on dose, route of administration (oral vs. injectable), steroid type (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Mesterolone is an oral non-aromatizable androgen and would be expected to have significant negative effects on lipids. Studies that gave 100 mg of mesterolone daily to hypogonadal men for approximately 6 months showed significant increases in total cholesterol (18.8%) and LDL cholesterol (65.2%), and mesterolone should not be used when cardiovascular risk factors preclude the use of other oral steroids. To help reduce cardiovascular strain, it is recommended that an active cardiovascular exercise program be maintained at all times during active AAS administration and that intake of saturated fat, cholesterol, and simple carbohydrates be minimized. Supplementation with fish oil (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Mesterolone Side Effects (Testosterone Suppression):
Mesterolone has a very weak inhibitory effect on gonadotropins and serum testosterone. Studies have shown that when administered at moderate doses (150 mg per day or less), no significant suppression of testosterone levels occurs. In studies using high doses of Mesterolone (300 mg per day and above), the drug strongly suppresses serum testosterone.
Dosage of Proviron To treat androgen insufficiency, Proviron is usually given at a dose of 1 tablet (25 mg) three times a day at the beginning of treatment. The drug is later continued at a lower maintenance dose, which usually involves taking 1 tablet (25 mg) one to two times a day. Similar doses are used to support male fertility, usually in conjunction with other fertility drugs such as injectable FSH. The usual dose for male athletes is 50 mg to 150 mg of Proviron per day, or 2 to 6 25 mg tablets. The drug is usually taken in cycles of 6-12 weeks, which is usually a sufficient time period to notice the benefits of drug treatment.
Many bodybuilders like to use mesterolone during dieting phases or competition preparation, because low estrogen and high androgen levels are particularly desired. This is especially useful when using drugs such as stanozolol, oxandrolone or primobolan alone, because these drugs are relatively low in androgen content. Mesterolone can be effectively used to upwardly regulate the ratio of androgens to estrogens, thereby increasing the hardness and density of muscles, supporting libido and a general sense of well-being, and increasing the tendency to burn body fat. When other aromatizing transestrogenic steroids are administered, it is also commonly used (at similar doses) to prevent gynecomastia in men, usually with 10-20 mg of tamoxifen per day.



That's about all the introductions to mesterol. Next, I'll tell you about my reaction to mesterol. When adding mesterol to a cycle, the first and most intuitive point is that during the period, your sexual desire and sexual function will not be affected. This is the most important thing. Taking 50-75mg a day can make your sexual function and erection just like in adolescence, when you were burning with desire in junior high and high school. In fact, all the technology, in the final analysis, is the most important point, whether there is liver toxicity and whether it will affect your own endogenous secretion. There is no doubt that mesterol has no effect in this regard, but when mesterol reaches When you take 300mg a day, it will directly suppress the gonads. When you take 150mg, I took it for 3 months. After stopping the drug, I didn't feel that my libido and erection were affected. Of course, I don't recommend taking 150mg. Taking 50-100mg can give you a good effect in the cycle. If you are a single dog without a girlfriend, you need to be cautious when adding mesterolone to the cycle, because this effect is like an aphrodisiac. It's really not an exaggeration. Mesterolone is like a faucet, which can lock our testosterone well and prevent it from leaking. That's about it for today's introduction.